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Tirzepatide Tops Semaglutide for A1c Control, Weight Loss Tirzepatide Tops Semaglutide for A1c Control, Weight Loss
A meta-analysis of studies on the two diabetes drugs shows stronger benefits with tirzepatide, with the caveat of some higher gastrointestinal effects with tirzepatide.Medscape Medical News
Source: Medscape Diabetes Headlines - September 23, 2023 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
No evidence of hepatitis E virus (HEV) infection among pet cats and dogs, and low seroprevalence of hepatitis E virus among pet rabbits in Poland
AbstractThe seroprevalence ofPaslahepevirus balayani genotype 3 (hepatitis E virus genotype 3 – HEV-3;Hepeviridae family, genusPaslahepevirus) in pet cats, dogs and rabbits was evaluated. Samples from cats and dogs were collected from three veterinary practices from various parts of Poland: Poznan (wielkopolskie voivodeship), Przemysl (podkarpackie voivodeship) and Lublin (lubelskie voivodeship). Samples from rabbits were collected in Poznan. In total, serum samples from 90 cats, 82 dogs and 71 rabbits were selected and tested for specific anti-HEV-3 immunoglobulin (IgG) antibodies using a commercial ELISA test. Pathogen...
Source: Veterinary Research Communications - September 23, 2023 Category: Veterinary Research Source Type: research
Months after hospitalization for COVID-19, MRIs reveal multiorgan damage
This study found abnormal MRI results in 20% to 25% of both controls and hospitalized patients, suggesting
“a lot of these cardiac abnormalities that were seen in the COVID group must have been there beforehand.” Post–COVID-19 patients with lingering cardiac symptoms might have disorders like heartbeat irregularities that aren’t always visible with MRI, or dysfunction in other organs, he adds.
Although it can offer clues to an organ’s health, MRI is an imperfect measure of how a patient is faring after infection. Researchers found no connection between abnormal liver MRIs and symptoms such as gastroin...
Source: ScienceNOW - September 22, 2023 Category: Science Source Type: news
Adipocyte glucocorticoid receptor inhibits immune regulatory genes to maintain immune cell homeostasis in adipose tissue
Endocrinology. 2023 Sep 20:bqad143. doi: 10.1210/endocr/bqad143. Online ahead of print.ABSTRACTGlucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood. We performed in vivo studies using adipocyte sp...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Shripa Amatya Dylan Tietje-Mckinney Schaefer Mueller Maria G Petrillo Matthew D Woolard Sushma Bharrhan A Wayne Orr Christopher G Kevil John A Cidlowski Diana Cruz-Topete Source Type: research
Fragmentation of Care in Patients with Peritoneal Metastases Undergoing Cytoreductive Surgery
CONCLUSIONS: There were no significant differences in survival or SAEs based on the networks of systemic therapy delivery. This suggests that patients undergoing CRS at a high-volume center may safely receive systemic therapy at outside-network facilities with comparable outcomes.PMID:37737968 | DOI:10.1245/s10434-023-14318-1
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Mason Vierra Varun V Bansal Ryan B Morgan Hunter D D Witmer Biren Reddy Ankit Dhiman Frederick A Godley Cecilia T Ong Erika Belmont Blas é Polite Ardaman Shergill Kiran K Turaga Oliver S Eng Source Type: research
Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
In this study, we investigated the role of STIM1 in the proliferation and fibrosis in high glucose (HG)-induced HBZY-1 cells. We found that the expression of STIM1 was increased in renal tissues of diabetic rat and HBZY-1 cells stimulated by HG. Downregulation of STIM1-mediated SOCE suppressed hyperglycemic cell proliferation and fibrosis by activating autophagy. In addition, the inhibitory effect of downregulating STIM1 on cells was blocked by autophagy inhibitor Bafilomycin A1 (BafA1). Moreover, this experiment also showed that STIM1 regulated autophagy, cell proliferation and fibrosis via PI3K/AKT/mTOR signal pathway. T...
Source: Molecular and Cellular Biochemistry - September 22, 2023 Category: Biochemistry Authors: Xixi Zeng Anbang Sun Weiyi Cheng Xin Hou Min Zhu Yanhong Liao Source Type: research
Herpetic Esophagitis: A Cause of Dysphagia in a Malnourished Patient
Cureus. 2023 Aug 21;15(8):e43858. doi: 10.7759/cureus.43858. eCollection 2023 Aug.ABSTRACTHerpetic esophagitis (HE) is an esophageal infection caused by herpes simplex virus (HSV). Although less common, it can occasionally affect immunocompetent hosts. It can manifest as odynophagia and/or dysphagia and should lead to an investigation by upper digestive endoscopy with a biopsy. The authors report a case of a 65-year-old man with a past medical history relevant for schizophrenia, oligophrenia, and malnutrition, and no other history or evidence of immunosuppression, who presented with severe dysphagia over weeks and recent e...
Source: Herpes - September 22, 2023 Category: Infectious Diseases Authors: B árbara Sousa Joana Silva Elsa Ara újo Raquel Costa Andre Calheiros Source Type: research
Results of surgical therapy of functioning pituitary adenomas
CONCLUSION: Surgical therapy in the presented cohort led to the normalisation of hormonal excessive production in 58.6% of cases. A combination of drug therapy and radiotherapeutic methods was necessary in the remaining cases to achieve hormonal remission.PMID:37737300 | DOI:10.5507/bp.2023.037
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 22, 2023 Category: Biomedical Science Authors: Vlastimil Novak Lumir Hrabalek Jan Schovanek Zdenek Frysak Racheal Temitope Ijisesan Perryova Daniel Pohlodek Source Type: research
Taxane-Based Chemotherapy Is Effective in Metastatic Appendiceal Adenocarcinoma
Oncologist. 2023 Sep 20:oyad263. doi: 10.1093/oncolo/oyad263. Online ahead of print.ABSTRACTAppendiceal cancer is a rare, orphan disease with no therapies currently approved by the FDA for its treatment. Given the limited data regarding drug efficacy, these tumors have historically been treated with chemotherapy designed for colon cancer. However, an overwhelming body of molecular data has demonstrated that appendiceal adenocarcinoma is a distinct entity with key molecular differences from colon cancer, notably rare APC mutation. Recognizing that APC loss-of-function is thought to contribute to taxane resistance and that t...
Source: The Oncologist - September 22, 2023 Category: Cancer & Oncology Authors: Julia Dansby Aditya More Mohammad Zeineddine Abdelrahman Yousef Alisha Bent Farshid Dayyani Robert Wolff Michael Overman John Paul Shen Source Type: research
Plasticity of gastrointestinal vagal afferents in terms of feeding-related physiology and pathophysiology
J Physiol. 2023 Sep 22. doi: 10.1113/JP284075. Online ahead of print.ABSTRACTGastrointestinal vagal afferents play an important role in communicating food related information from the gut to the brain. This information initiates vago-vagal reflexes essential for gut functions, including gut motility and secretions. These afferents also play a role in energy homeostasis, signalling the arrival, amount and nutrient composition of a meal to the central nervous system where it is processed ultimately leading to termination of a meal. Vagal afferent responses to food related stimuli demonstrate a high degree of plasticity, resp...
Source: The Journal of Physiology - September 22, 2023 Category: Physiology Authors: Amanda J Page Source Type: research
Definitive carbon ion re-irradiation with pencil beam scanning in the treatment of unresectable locally recurrent rectal cancer
In conclusion, definitive carbon ion re-irradiation with PBS provided superior oncologic results with tolerable toxicities and may be served as a curative treatment strategy in unresectable LRRC.PMID:37738440 | DOI:10.1093/jrr/rrad068
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Xin Cai Ping Li Jingfang Zhao Weiwei Wang Jingyi Cheng Guangyuan Zhang Sanjun Cai Zhen Zhang Guoliang Jiang Qing Zhang Zheng Wang Source Type: research
Taxane-Based Chemotherapy Is Effective in Metastatic Appendiceal Adenocarcinoma
Oncologist. 2023 Sep 20:oyad263. doi: 10.1093/oncolo/oyad263. Online ahead of print.ABSTRACTAppendiceal cancer is a rare, orphan disease with no therapies currently approved by the FDA for its treatment. Given the limited data regarding drug efficacy, these tumors have historically been treated with chemotherapy designed for colon cancer. However, an overwhelming body of molecular data has demonstrated that appendiceal adenocarcinoma is a distinct entity with key molecular differences from colon cancer, notably rare APC mutation. Recognizing that APC loss-of-function is thought to contribute to taxane resistance and that t...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Julia Dansby Aditya More Mohammad Zeineddine Abdelrahman Yousef Alisha Bent Farshid Dayyani Robert Wolff Michael Overman John Paul Shen Source Type: research
The impact of intensified staging and combined therapies in locally advanced pancreatic cancer: a secondary analysis of prospective studies
CONCLUSIONS: The use of comprehensive pre-treatment staging, including laparoscopy and 18F-FDG-PET/CT scan, is an effective approach in identifying occult metastatic disease in LAPC patients. Our findings offer valuable insights into accurate staging and treatment efficacy, providing evidence-based support for optimal management strategies in LAPC patients.PMID:37737898 | DOI:10.1097/JS9.0000000000000755
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Michele Fiore Gian Marco Petrianni Pasquale Trecca Gabriele D'Ercole Alessandro Coppola Vincenzo La Vaccara Silvia Taralli Paola Cimini Carlo Greco Edy Ippolito Maria Lucia Calcagni Bruno Beomonte Zobel Damiano Caputo Roberto Coppola Sara Ramella Rolando Source Type: research
Multi-disciplinary management of recurrent gastrointestinal stromal tumor harboring KIT exon 11 mutation with the switch-control kinase inhibitor ripretinib and surgery
Oncoscience. 2023 Sep 20;10:38-43. doi: 10.18632/oncoscience.586. eCollection 2023.ABSTRACTRipretinib is a tyrosine kinase inhibitor that was approved by the United States FDA in 2020 for treatment of advanced gastrointestinal stromal tumor (GIST) in patients who received prior treatment with three or more tyrosine kinase inhibitors. In this case report, we show the durable clinical benefit achieved in a patient with GIST by using ripretinib and repeated timely surgical resection of limited disease progression. The total time on ripretinib was 43 months which is longer than the current reported data from ripretinib clinica...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mohamed A Gouda Filip Janku Neeta Somaiah Kelly K Hunt Sireesha Yedururi Vivek Subbiah Source Type: research
Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis
J Orthop Surg Res. 2023 Sep 22;18(1):713. doi: 10.1186/s13018-023-04119-3.ABSTRACTOsteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce only symptomatic relief. Platelet-rich plasma (PRP) is a platelet concentrate derived from autologous whole blood with a high concentration of platelets, which can exert anti-inflammatory and regenerative effects by releasing multiple growth factors and cytok...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai Source Type: research
